The Disease ...
Disease is a state of disturbed homoestasis,a state of some kind of abnormality apparent at either gross or microscopic or both levels.Since life and living beings are chemical at the core of their existence,a disease is essentially when some thing ,somewhere goes wrong with the normal physiological chemistry or biochemistry.that is why the medicine is all about enormous number of drugs ,which are actually the chemicals supposed to restore the lost homeostasis back to original state.
Obviously the disease is as old as life itself.Almost all forms of life are predisposed to get diseased in one way or the other,whether it is a bacteria or a human being.However there more sophisticated is the organism,more elaborated are the homeostatic mechanisms and more likely they are to perturbations and hence getting diseased.
Disease can be due to genetic reasons,this is actually from chemical perspective, a very fundamentally defective state,quite permanent in nature.In genetic disorders, the genetic material is not expressing what it should have been, for a balanced homeostasis.and for the whole life time of the individual it would keep on expressing the same faulty information.and the worst part is ,it can't be restored and rectified to express the correct information.A cell has no way to understand that what is being expressed from the DNA is not a normal information and even if somehow the cell knows this,it has no means to rectify the faulty bio-information in DNA to the correct one.
However in diploid organisms like human beings the problem has been solved to a great extent by having two copies of every gene and every chromosome.This provision however suffers a trouble in males where the sex chromosomes are not X and X (as in females) but it is rather X and Y.so there is actually no back up for any defective gene in X or Y chromosome in males.that is why males suffer from sex-linked diseases so readily.Males manifest the abnormality and females enjoy the privilege of just being "carriers".
More commonly the diseases are caused by infectious agents.the infectious agents are microorganisms like bacteria ,viruses,parasitic protzoans ,fungi and many more.the microorganisms have a short generation time,they are always busy in multiplying themselves and given their simple existence quite at mercy of their ambient conditions, they have no choice except a life style where quick multiplication is the only goal and way to survive in the race of time.microorganisms needs a protective niche more than multicellular organisms do,this is because of their limited ability to adapt and greater likelihood of natural death of their unicellular existence.
The Microbial sin of Disease
a vast majority of microbes do not actually want to kill us.this would be a loss of host to them.a successful way is to keep the host alive and thrive and multiply well within the warm ,nutrient rich confines of host.then how do they cause disease in host?. the microbes are multiplying in host and in this act they are disturbing the fine balance of homeostasis in host system.
i will have more to say about the disease in subsequent sections.......Inshallah..
